The pisiform growth plate is lost in humans and supports a role for Hox in growth plate formation
نویسندگان
چکیده
منابع مشابه
Growth Plate and Cellular Growth
The growth plate is a highly organized cartilage structure with a complex cellular biology. Studies have been limited by the relative lack of relevant experimental models. Thanks to new technologies, e.g. targeted deletions of genes, knowledge is rapidly expanding. The first paper selected representing the mechanism of the year describes how estradiol can rescue skeletal growth during GH resist...
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We studied the cellular response to physeal distraction in the growth plates of skeletally immature rabbits. We used a new method of labelling and detection of proliferating cells with bromodeoxyuridine (BUdR) and an anti-BUdR antibody. The application of an external fixator but no distraction force produced no changes in the growth plates. After five days of distraction at a maximum force of 2...
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In mammals, growth of long bones occurs at the growth plate, a cartilage structure that contains three principal layers: the resting, proliferative, and hypertrophic zones. The function of the resting zone is not well understood. We removed the proliferative and hypertrophic zones from the rabbit distal ulnar growth plate in vivo, leaving only the resting zone. Within 1 wk, a complete prolifera...
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Longitudinal bone growth is rapid in prenatal and early postnatal life, but then slows with age and eventually ceases. This growth deceleration is caused primarily by a decrease in chondrocyte proliferation, and is associated with other structural, functional, and molecular changes collectively termed growth plate senescence. Current evidence suggests that growth plate senescence occurs because...
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Differentiation is the cellular process that regulates development of long bones and joint surface cartilage of synovial cavities. Growth plate cartilage development is commonly referred to as endochondral ossification which is the end stage of long bone development. Endochondral ossification proceeds as a continuum of chondrocyte proliferation cycles followed by non-proliferative phases couple...
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ژورنال
عنوان ژورنال: Journal of Anatomy
سال: 2014
ISSN: 0021-8782
DOI: 10.1111/joa.12235